Rocksmith is very good way to get yourself learning guitar but if your trying to learn from watching YouTube videos well you cant have Rocksmith in the background.

RsMods has loads of settings to tweak Rocksmith 2014
https://github.com/Lovrom8/RSMods/releases/

Some of things you can do;

Some of the things you can do with RSMods on PC:

• Disable the loft / amps / skyline (all black background streamer mode), and many more of the in song elements
• Enable the hidden Direct Connect input mode
• Speed Up the game start up process
• Auto Load last used profile
• Remove most of the “Custom Tuning” definitions
• Set your own names for the in game Song Lists
• Automatically control your Digitech Whammy DT, or other midi signal controllable drop tuning pedals
• Control the game menus with your guitar
• Customize String Colors – be that for your own ColorBlind choices, or Extended Range guitar and bass use
• Automatically Enumerate whenever a new CDLC is added to your game

Source Post;

Any way to play guitar with the tones but have the screen minimized?
byu/SarcasticallyCandour inrocksmith